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It should really also be noted that there are research that have failed to help a central part for serotonin. In a number of studies, the metabolites five-HT and 5-HIAA in the cerebral spinal fluid of pathological gamblers had been unchanged (Roy et al., 1988, 1989 Bergh et al., 1997). Research did come across, even so, evidence of elevated noradrenergic activity. The metabolite of noradrenaline, MHPG, was increased in pathological gamblers (Roy et al., 1988, 1989). Bergh et al. (1997) confirmed that discovering and reported an boost in the concentration of noradrenaline. Other research that implicate serotonin have measured platelet monoamine oxidase (MAO) levels. Platelet MAO activity, a peripheral marker of 5-HT function, was located to be reduce in gamblers compared with nongamblers (Carrasco et al., 1994). In 1996, with a slightly larger sample (27 gamblers and 27 matched controls), Blanco and colleagues identified evidence to assistance the Carrasco acquiring (Blanco et al., 1996).

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