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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are typically described by their focus on practical aspects of designing a study which include the recruitment process and consent, adhering and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and included participants from different geographical regions. This type of heterogeneity is necessary for practical trials to be valid, and it also helps reduce the chance of bias in the results. However, too much heterogeneity can cause issues with the design of the trial.

Pragmatic Play Pragmatic Play, one of the major players in the live casino market offers an array of traditional table games, including Blackjack and Roulette. The live studios of the company in Romania and Malta offer a real-life gaming experience for its customers and offer an extensive selection of virtual betting options. The company also has created numerous interactive game shows that make online gambling enjoyable. Some of these shows feature live hosts, while others are hosted by famous personalities from the industry.

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Pragmatic Play has gained a reputation for offering top-quality games and an outstanding user experience. Its software is designed to work on mobile devices and is compatible with multiple languages. Despite its relative youth it has already established itself as a top casino gaming platform. Its latest releases include Wolves 5 reel video slot with a healthful RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually commissioned by policy makers and practitioners to guide their decision-making. They are also a good method of determining the causal relationship between the intervention and its effects. However, they should not be used to replace explanatory studies.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials can replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform the policy and practice of. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the features of a pragmatic study which includes the recruitment process, the design and delivery of the intervention, as well as monitoring.

There is a growing increase in the number of pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health science community is becoming more sensitive to the subject of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.